Vampire: The Masquerade – Bloodlines 2 carries forward the legacy of its cult-classic predecessor, putting players in the middle of the Camarilla-ruled streets and Anarch undergrounds of modern Seattle. While your path will depend on the clan and choices you make, every player follows a structured narrative of main missions interlaced with side quests that reveal the hidden politics, betrayals, and supernatural power struggles defining this dark world.
Main Questline Overview
The Bloodlines 2 revolves around 21 main story missions, each pushing the player deeper into the mystery surrounding Seattle’s vampiric hierarchy. You’ll switch perspectives between Phyre, an Elder vampire awakened in a new century, and Fabien, whose flashbacks piece together key historical moments that shaped the modern Kindred order.
Here’s the complete main quest list, roughly following the story’s progression:
- The Cigarette Girl
- The Fires of Industry
- In Chains of Lead and Gold
- Prove Yourself
- In Memoriam
- To Founder on the Lethe
- A Work of Holy Innocents
- Blood Sisters – The Night Out
- Keep the Peace
- The Prince of Seattle
- We Don’t Do Ghost Stories
- Chewing the Fat
- The Pathway of Hesperides
- As Above, So Below
- The Mother
- The Streets Incarnadine
- Service, Pride, and Dedication
- In Fingertips of Rose
- The Coursing of the Rats
- A Kiss from Prospero
- Seattle’s New Normal
Each mission builds upon the last, taking players from political dealings in vampiric courts to haunting encounters in the city’s underground. Missions like A Work of Holy Innocents and The Pathway of Hesperides feature major boss fights and narrative branching points, while The Prince of Seattle and Service, Pride, and Dedication act as turning points leading toward one of several possible endings.
Side Quests and Collectible Chains
While Bloodlines 2 is primarily focused on its main story, it offers three major side quest chains tied to exploration and collectibles. Each chain contributes XP, lore, and Blood Resonance to enhance your abilities.
1. Anarch Tags
- Quest Giver: Fletcher (Makom Bar)
- Objective: Collect 30 glowing Anarch graffiti tags scattered across Seattle.
- Reward: 2,000 XP
These tags represent the rebellious Anarch movement, giving subtle world-building insights into their ideology and history.
2. I.A.O. Surveillance Cameras
- Quest Giver: Silky (The Dutchman)
- Objective: Disable 30 surveillance cameras installed by the I.A.O. (the anti-vampire organization).
- Reward: 2,000 XP
Each disabled camera reduces mortal awareness, keeping your Masquerade intact and unlocking unique dialogue later in the game.
3. Crosses of Saint James
- Quest Giver: Patience (Aurora Pawn)
- Objective: Find nine hidden gold crosses within key story locations.
- Reward: 2,000 XP
These relics hint at Seattle’s deep history with the Church and its darker connection to vampiric relic hunting.
You’ll need to finish these side activities before entering Weaver Tower during The Coursing of the Rats, as there’s no way to backtrack once the late-game sequence begins.
Estimated Playtime
| Playstyle | Average Duration |
|---|---|
| Main Story Only | 20–25 hours |
| Main + Side Quests | 35–40 hours |
| Completionist (All Clans & Endings) | 60–80 hours |
Your total time largely depends on the chosen difficulty and whether you pursue all clan endings. Since Bloodlines 2 encourages multiple playthroughs to explore different Elder lineages and moral outcomes, true completionists can expect well over 70 hours of gameplay.
Summary Table – Main and Side Content
| Type | Quest/Chain | Key Features |
|---|---|---|
| Main Questline | 21 Story Missions | Dual narratives (Phyre/Fabien), branching endings |
| Side Activity 1 | Anarch Tags | Explore Seattle’s hidden streets |
| Side Activity 2 | I.A.O. Cameras | Stealth and world-control rewards |
| Side Activity 3 | Crosses of Saint James | Religious artifacts and lore |
| Bonus Choices | Clan Contacts | Unlock new abilities and powers |
| Replay Incentive | Six Clan Endings | Multiple fates for Seattle |
With its intricate questlines and morally gray choices, Vampire: The Masquerade – Bloodlines 2 doesn’t just ask you to complete missions — it challenges you to define what kind of monster you’ll become. Each quest, whether a fleeting encounter or a major decision, reinforces one theme: power always comes at a price, and in Seattle, blood is the currency. Play Now!
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